Cooling helps to maintain sample integrity, but when deliberate changes of samples are required prior to injection, heat is our best help. HotCap™ is a piece of capillary tubing that can be heated up to 100°C. When used as sample loop or other positions in the sampling line, samples or sample/reagent mixtures can be heated before injection. Typical applications include pre-column derivatization, protein denaturing to reduce protein-analyte binding, disruption of cells, etc. HotCap™ heats up in seconds, has actual temperature read-out and a hardwired temperature limiter for maximum safety.